Backup running backs may not garner the same excitement as starting players in fantasy football leagues, yet the strategic selection of handcuffs can significantly influence a team's success, determining the difference between a championship victory and missing the playoffs. The task of identifying these players can be challenging, particularly as the line between starters and backups often blurs due to the modern NFL's use of platoon approaches. Furthermore, the unpredictable nature of injuries and player performance can result in rapid changes to depth charts, heavily impacting fantasy outcomes.

For the 2025 season, a ranked overview is provided that combines each NFL team’s handcuff running back based on their standalone value and potential upside if called into a starting role. This evaluation takes into consideration training camp reports, snap count statistics, and previous season usage trends. For instance, Kendre Miller of the New Orleans Saints once stood out as a promising handcuff, but his performance has not met expectations, resulting in limited roster consideration outside of the deepest fantasy leagues. His career totals of just 454 yards and two touchdowns on 95 touches over 14 games highlight the struggles he has faced, largely attributed to injuries.

In contrast, the Cincinnati Bengals may have found a promising talent in Chase Brown, although the primary workload is expected to go to the established running back. The situation in Green Bay is complex, as second-year player Louderback Lloyd faces competition and the specter of ongoing injuries. Meanwhile, Saquon Barkley’s successful tenure with the Philadelphia Eagles has positioned him as the main contributor, minimizing the fantasy relevance of his backups. As franchises navigate these dynamics, identifying valuable handcuffs for fantasy rosters becomes paramount, particularly for players like DJ Giddens of the Indianapolis Colts, who has potential as an RB1 should the starter struggle to remain healthy. Extensive analysis of the running back situation across each NFL team will further guide fantasy managers as they prepare for the upcoming season.