In a comprehensive review of Major League Baseball's history over the past quarter-century, Moneyline showcases exceptional talent across every franchise with a focus on second basemen. This analysis highlights standout players and includes some widely accepted choices, such as Dustin Pedroia for the Boston Red Sox and Chase Utley for the Philadelphia Phillies. However, many selections warrant discussion and varying opinions. The evaluation is based solely on statistics gathered since the onset of the 2000 season, meaning that players like Hall of Famer Craig Biggio, despite his Hall of Fame status, are only considered for their performance during this time frame. Various factors including offensive output, defensive capabilities, individual honors, and postseason achievements were considered in determining the best second baseman for each franchise. In cases of close competition, peak performance was prioritized over longer but less impactful careers.

Ketel Marte stands out as a critical acquisition for the Arizona Diamondbacks, obtained in a trade with the Seattle Mariners. His breakout 2019 season was notable, as he posted a remarkable 149 OPS+ with 32 home runs while finishing fourth in NL MVP voting. Since that season, Marte has emerged as one of the most productive offensive players in the league, setting a postseason record with a 20-game hitting streak during the Diamondbacks' recent World Series appearance and achieving a splendid 155 OPS+ in the 2023 season. Honorable mentions for Arizona also include Orlando Hudson, Aaron Hill, and Kelly Johnson.

Mark Ellis, often overlooked, brought outstanding defense and offensive versatility during his tenure with the Oakland Athletics. Between 2005 and 2008, he amassed an impressive 16.1 WAR in just over 500 games, ranking behind only Chase Utley, Brian Roberts, and Plácido Polanco among all second basemen in that time frame. In contrast, Ozzie Albies has made a significant impact since his debut with the Atlanta Braves in 2017, cementing his status as a pivotal player in the team's ascent by earning an All-Star nod and a Silver Slugger Award shortly thereafter. Throughout his career, Albies has consistently demonstrated his all-around abilities, registering impressive statistics as he continues to grow into a cornerstone of the Braves' lineup. Meanwhile, Baltimore Orioles' Brian Roberts displayed a blend of speed and power, achieving notable success with multiple All-Star selections and a peak performance that saw him average excellent offensive numbers over a six-year stretch.