Following the Buffalo Bills' victory over the Kansas City Chiefs, which marked the Chiefs' first loss of the season, quarterback Patrick Mahomes voiced his perspective that the match could serve as a preview for the playoffs. In a post-game exchange at midfield with Bills quarterback Josh Allen, Mahomes remarked, 'We'll do it again, baby.' This comment encapsulated the competitive spirit shared between the two standout quarterbacks.

With the outcome of the game, Kansas City fell to a 9-1 record, while Buffalo improved to 9-2, positioning itself strongly in pursuit of the top seed in the AFC. Mahomes' performance included a vital third touchdown pass—a one-yard completion to tight end Noah Gray—bringing the Chiefs within two points of the Bills as the game approached its final moments. However, the momentum shifted back to Buffalo when Allen rushed for a decisive 26-yard touchdown, extending the lead to 30-21 with just 2:17 left on the clock. Despite the urgent need for Kansas City to score again, Mahomes was unable to complete the comeback, as he was intercepted by Bills linebacker Terrel Bernard during a crucial fourth-down play.

Since their first encounter in 2020, the Chiefs and Bills have engaged in an evenly matched rivalry, each team claiming a share of victory with a 4-4 record across regular-season and playoff contests. Notably, the Bills have triumphed over the Chiefs in four consecutive regular-season matchups; however, Kansas City has prevailed in all three playoff meetings over the last four years, including a tightly contested 27-24 win during last season's AFC Divisional Round. Analysts had speculated that Buffalo might experience a downturn this season after an offseason featuring significant changes, including the trade of wide receiver Stefon Diggs to the Houston Texans and the release of several key veterans. Contrary to these predictions, the Bills currently hold a commanding 4.5-game lead over the Miami Dolphins in the AFC East, positioning themselves for a potential fifth consecutive division title and a sixth playoff appearance in a row. While the Bills continue to seek a coveted first-round bye through the No. 1 seed in the playoffs, their recent victory over Kansas City has significantly bolstered their aspirations for that goal. The Chiefs have demonstrated their ability to defeat the Bills on the road in the playoffs, but should a rematch occur, the extra week of rest afforded to Buffalo might prove to be a crucial advantage. As history suggests, the likelihood of another face-off between the Bills and Chiefs in January remains high.