Week 6 of the 2025 NFL Season Is Here

As we dive into Week 6 of the 2025 NFL campaign, the fantasy football landscape is heating up. While some lucky managers maintain perfect records with teams at 5-0 or 4-1, others are desperately seeking ways to turn their season around. This week, we provide you with essential position-by-position PPR rankings, breakout and bust candidates, sleeper picks, and overall flex options to enhance your fantasy team.

Quarterback Rankings

Injuries have played a significant role in the quarterback scene this season, with notable players like Lamar Jackson and Jayden Daniels missing games or sitting out in Week 6. Nevertheless, Dak Prescott (Dallas Cowboys, QB5) and Drake Maye (New England Patriots, QB7) are making headlines as value picks.

Players to Watch

• Justin Herbert, Los Angeles Chargers (at MIA) - DraftKings DFS Value: $6,300Questionable numbers this season, but expect a shift towards a pass-heavy strategy with injuries in the backfield.
• Matthew Stafford, Los Angeles Rams (at BAL) - DraftKings DFS Value: $6,400Ranked sixth in fantasy points among QBs; strong performance anticipated against a struggling Ravens secondary.

Players to Avoid

• Daniel Jones, Indianapolis Colts (vs. ARI) - DraftKings DFS Value: $6,000The Cardinals have a robust defense, limiting QB points.
• Kyler Murray, Arizona Cardinals (at IND) - DraftKings DFS Value: $5,700underwhelming performance and facing injuries make him a risky start.

Running Back Rankings

Saquon Barkley remains a top-10 option despite injury concerns. Meanwhile, players like Josh Jacobs and Ashton Jeanty are looking to break out.

Players to Watch

• Josh Jacobs, Green Bay Packers (vs. CIN) - DraftKings DFS Value: $7,300Four touchdowns already, but needs to improve on yardage against a vulnerable Bengals defense.
• Ashton Jeanty, Las Vegas Raiders (vs. TEN) - DraftKings DFS Value: $6,900Due for a breakout as he faces the Titans, who struggle against the run.

Players to Avoid

• Chase Brown, Cincinnati Bengals (at GB) - DraftKings DFS Value: $5,600Low yardage numbers make him a non-starter.
• Derrick Henry, Baltimore Ravens (vs. LAR) - DraftKings DFS Value: $6,200His recent performance indicates ongoing struggles against a solid Rams defense.

Wide Receiver Rankings

Ja'Marr Chase’s performance fluctuated, which raises questions about his reliability moving forward.

Players to Watch

• Davante Adams, Los Angeles Rams (at BAL) - DraftKings DFS Value: $6,700A favorable matchup against a depleted Ravens secondary.
• A.J. Brown, Philadelphia Eagles (at NYG) - DraftKings DFS Value: $5,700A high-value pick based on his potential to bust out against the Giants.

Players to Avoid

• Keon Coleman, Buffalo Bills (at ATL) - DraftKings DFS Value: $5,300Limited production makes him a risk.
• Garrett Wilson, New York Jets (vs. DEN) - DraftKings DFS Value: $6,300Facing tough coverage could limit his effectiveness.

Tight End Rankings

Jake Ferguson continues to establish himself as a top fantasy choice, with significant targets throughout the season.

Players to Watch

• Hunter Henry, New England Patriots (at NO) - DraftKings DFS Value: $4,300Possible bounce-back against the Saints.
• Tucker Kraft, Green Bay Packers (vs. CIN) - DraftKings DFS Value: $4,700Can benefit from a favorable matchup.

Players to Avoid

• Dallas Goedert, Philadelphia Eagles (at NYG) - DraftKings DFS Value: $4,000Struggles this season make him less appealing.
• Darren Waller, Miami Dolphins (vs. LAC) - DraftKings DFS Value: $4,000Facing a tough matchup that could limit his production.

Team Defense and Kicker Rankings

The top defenses highlight a mix of surprising teams and established ones. Streaming based on matchups continues to be a practical strategy.

Players to Watch

• Green Bay Packers Defense (vs. CIN) - DraftKings DFS Value: $3,700A strong option against the Bengals' uncertain quarterback situation.
• Wil Lutz, Denver Broncos (at NYJ) - Teams are scoring on the Jets, making Lutz a viable kicker option.

Players to Avoid

• Seattle Seahawks Defense (at JAX) - DraftKings DFS Value: $2,700Struggling coming off a tough game against a high-scoring team.
• Jason Myers, Seattle Seahawks (at JAX) - Limited scoring opportunities against tough defense.

Conclusion

As the NFL season progresses, savvy managers will need to adapt their strategies. Focus on matchups, keep an eye on injury reports, and continue refining your team as we move through Week 6.